Welcome to the HOPE-e study website.
We invited women aged 40-65, who were at least 1 year after menopause, and were experiencing hand pain due to osteoarthritis (OA), to take part in this study.
Purpose of the study: We want to test whether taking a tablet of an estrogen-containing therapy once daily for 6 months improves hand pain in women with hand OA, when compared with taking a placebo tablet (inactive medication). This study aims to find out whether it is acceptable to women with painful hand OA to take this type of treatment, and also what the best way of collecting some of the information is, to help us plan a full size trial. The study may also give us some idea of whether this treatment might work or not.
The HOPE-e study has now finished. Please click the NEWS tab above to access the study results.
The HOPE-e study is being led and managed by the Oxford Clinical Trials Research Unit (OCTRU) in collaboration with the University of Oxford and Oxford University Hospitals NHS Trust.
The National Institute for Health Research (NIHR) is funding this study, via their ‘Research for Patient Benefit’ programme. The study also benefits from resources including staff time provided by the Centre for OA Pathogenesis Versus Arthritis, which is based in Oxford.
October 2022: Full study results published in The Lancet Rheumatology Journal. Click on the NEWS tab for more information.
December 2021: Focus groups with study participants
02 November 2021: Database lock and commencement of data analysis
19 August 2021: Last participant's last study visit
21 December 2020: The HOPE-e study closes recruitment.
06 October 2020: White Horse Medical Practice (Faringdon) re-opens recrutiment following the Coronavirus pandemic. All sites now open for recruitment!
29 August 2020: Charing Cross Hospital, London re-opens recrutiment following the Coronavirus pandemic.
04 August 2020: Nuffield Orthopaedic Centre, Oxford, re-opens recrutiment following the Coronavirus pandemic.
16 March 2020: HOPE-e recrutiment closes due to Coronavirus pandemic.
13 June 2019: White Horse Medical Practice (Faringdon) open to recruitment.
24 May 2019: Our second site, Charing Cross Hospital, opens to recruitment.
09 May 2019: HOPE-e opens to recruitment! The first site to open is the Nuffield Orthopaedic Centre, Oxford.
